Pakistan have been bowled out for 237 in their allotted 50 overs in the fourth and final day-night international at Dubai Stadium.
Asad Shafiq topscored with 65 while Azhar Ali (58) and Misbah-ul Haq (46) were the other contributors.
For England, paceman Jade Dernbach finished with 4-45.
England lead the series 3-0.
